Application of Polysorbate 80 in Preparation of Test Product

1. What is polysorbate 80? polysorbate hlb , the chemical name is polyoxyethylene 20 sorbitan monooleate, is a non-ionic surfactant, has significant adaptability to different pH, and is relatively stable when coexisting with high-concentration electrolytes. The water-lipophilic balance value ( polysorbate 80 hlb value ) is 15. It has strong hydrophilicity and is miscible with water, methanol, ethanol, chloroform and ethyl acetate. It is widely used in injections and oral preparations as O/W (water oil-in-oil) type emulsifier, solubilizer, wetting agent. Studies have shown that when hlb polysorbate 80 reaches a certain critical micelle concentration, the hydrophobic parts of its molecules attract each other and combine to form micelles. The formed spheroids, the solubilized substances, combine with the micelles in different ways, thereby increasing the dissolution of the drug components, but the solubilization effect is different from the real dissolution effect. ...